Isopropylphenidate (IPPH) is a phenidate class stimulant that appeared in the research chemical market in the 2010s. It primarily offers functional stimulation and comes with little recreational potential.
The substance is often said to be relatively good for focus and it could potentially be a good drug for those with ADHD. However, due to its research chemical status, we don’t know the drug’s long-term safety, check more at mega chem labs webshop
Increased heart rate
Increased blood pressure
IPPH largely lacks recreational and euphoric potential. Most people find common doses provide little more than a minor mood boost and improved task enjoyment. Even as the dose increases, it doesn’t become an especially fun stimulant. This means it’s really geared towards productive applications, like studying and working.
Some of the intranasal use reports mention a brief euphoric “rush.”
It can be good for talking, though some people prefer to work, not talk.
The substance is clear-headed with its mental effects, allowing people to remain focused and not distracted by their own thinking or other tasks. This could stop being the case with strong+ doses, which can increase task-switching and infringe upon productivity.
Because people are more content with whatever they’re working on and they may be more motivated, it’s easier to get through boring tasks.
The focus it provides typically doesn’t lead to strong “tunnel vision,” so it’s easier to break way from a task than with some other stimulants.
It’s fairly relaxed with the way it feels physically. Users typically don’t need to move around much, sweating isn’t significant, and the cardiac activity isn’t highly noticeable. Vasoconstriction could appear, though it’s not usually uncomfortable.
Compared to other stimulants
The substance is often said to be more subtle than other stimulants. It can elevate your mood to a minor degree and provide some stimulation, but it doesn’t extend much beyond that.
Many people have reported it feels as good as methylphenidate from a purely functional perspective. Sometimes it may even feel better due to a relative lack of somatic effects and “speediness,” so it’s been suggested to be a particularly good ADHD drug.
Because of this effect profile, some people have already jumped to using it daily or near-daily. This isn’t recommended since it is a research chemical and little is known about its safety.
It could be lacking in the strong pro-motivation effects seen with other stimulants, though the rise in motivation may still be adequate to help people.
As long as you use a common dose, it can offer caffeine-like levels of focus enhancement and productivity, but without the somatic jitteriness.
The comedown, if it exists, is almost always mild. There are some reports of lower motivation, lower mood, a higher likelihood of agitation, insomnia, and headache. Usually the symptoms only persist for a few hours, at most.
Chemistry & Pharmacology
IPPH is a member of the phenidate class of compounds, which are all esters of ritalinic acid and its analogs.
The most notable member of this class is methylphenidate. IPPH differs from that substance by the substitution of an isopropyl moiety in place of a methyl moiety.
It functions as a norepinephrine-dopamine reuptake inhibitor (NDRI). This means it blocks the reuptake of dopamine and norepinephrine, effectively boosting their functional concentrations.
Compared to methylphenidate, it has significantly less impact on norepinephrine, pushing it closer to a pure dopamine reuptake inhibitor. This could potentially reduce its wakefulness effects, but it may also reduce the chance of some physical negatives like cardiovascular stimulation.
Like methylphenidate, its primary metabolite is ritalinic acid, an inactive substance. In conclusion this metabolism occurs via the action of carboxylesterase 1 (CES1). IPPH seems to be a poorer substrate for CES1, which could slow down its metabolism and contribute to its lower dose range.